REF’s picks

CD Once Caldas arrive in superior defensive form and can frustrate Independiente Santa Fe, making the away win an appealing value option. Santa Fe are dealing with notable absences and have been vulnerable to counter-attacks recently. However, Once Caldas can sometimes struggle to convert their chances into goals, which keeps this tie finely balanced.

1. 1Once Caldas are unbeaten in their last five matches with a very solid defensive record.
2. 2Santa Fe are missing several key players through injuries and come off a tough defeat against Atlético Nacional.
3. 3Once Caldas occasionally lack clinical finishing despite creating plenty of openings in away games.

REF's own opinion, not a guarantee — nothing here is financial or betting advice, and the call is always yours.