REF’s picks

Independiente Medellín hold the edge at home against a heavily depleted Santa Fe side missing several key players. Backing the hosts makes sense given the visitors' extensive absentee list and historical struggles in this fixture.

1. 1Santa Fe travels with a severely weakened squad featuring multiple sidelined regulars.
2. 2Medellín desperately needs three points to climb higher in a tightly packed league table.
3. 3The hosts have been inconsistent recently and could struggle to break down a stubborn defensive setup.

REF's own opinion, not a guarantee — nothing here is financial or betting advice, and the call is always yours.